Sciweavers

Share
CCE
2005

Numerical simulation of stochastic gene circuits

9 years 3 months ago
Numerical simulation of stochastic gene circuits
Armed with increasingly fast supercomputers and greater knowledge of the molecular mechanisms of gene expression, it is now practical to numerically simulate complex networks of regulated biological reactions, or gene circuits. Using an exact stochastic simulation algorithm, we obtain an accurate time-evolution of the behavior of complex gene circuits, including the effects of fluctuations caused by highly dilute, but significant, regulatory proteins. Specifically, we examine an important gene circuit, the bistable switch, and use the stochastic simulation algorithm to develop design principles that will enable us to produce a fast and robust switch for use in future applications. We pay particular attention to different transcriptional control mechanisms and their effects on the amount of fluctuations in the system, emphasizing methods that increase certainty and improve the switching rate.
Howard Salis, Yiannis N. Kaznessis
Added 15 Dec 2010
Updated 15 Dec 2010
Type Journal
Year 2005
Where CCE
Authors Howard Salis, Yiannis N. Kaznessis
Comments (0)
books