Sciweavers

Share
PRIB
2010
Springer

An On/Off Lattice Approach to Protein Structure Prediction from Contact Maps

10 years 14 days ago
An On/Off Lattice Approach to Protein Structure Prediction from Contact Maps
Abstract. An important unsolved problem in structural bioinformatics is that of protein structure prediction (PSP), the reconstruction of a biologically plausible three-dimensional structure for a given protein given only its amino acid sequence. The PSP problem is of enormous interest, because the function of proteins is a direct consequence of their three-dimensional structure. Approaches to solve the PSP use protein models that range from very realistic (all-atom) to very simple (on a lattice). Finer representations usually generate better candidate structures, but are computationally more costly than the simpler on-lattice ones. In this work we propose a combined approach that makes use of a simple and fast lattice protein structure prediction algorithm, REMC-HPPFP, to compute a number of coarse candidate structures. These are later refined by 3Distill, an off-lattice, residue-level protein structure predictor. We prove that the lattice algorithm is able to bootstrap 3Distill, whic...
Stefano Teso, Cristina Di Risio, Andrea Passerini,
Added 14 Feb 2011
Updated 14 Feb 2011
Type Journal
Year 2010
Where PRIB
Authors Stefano Teso, Cristina Di Risio, Andrea Passerini, Roberto Battiti
Comments (0)
books