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ISBI
2008
IEEE

An optimal-path approach for neural circuit reconstruction

11 years 12 months ago
An optimal-path approach for neural circuit reconstruction
Neurobiologists are collecting large amounts of electron microscopy image data to gain a better understanding of neuron organization in the central nervous system. Image analysis plays an important role in extracting the connectivity present in these images; however, due to the large size of these datasets, manual analysis is essentially impractical. Automated analysis, however, is challenging because of the difficulty in reliably segmenting individual neurons in 3D. In this paper, we describe an automatic method for finding neurons in sequences of 2D sections. The proposed method formulates the problem of finding paths through sets of sections as an optimal path computation, which applies a cost function to the identification of a cell from one section to the next and solves this optimization problem using Dijkstra’s algorithm. This basic formulation allows us to account for variability or inconsistencies between sections and to prioritize cells based on the evidence of their c...
Elizabeth Jurrus, Ross T. Whitaker, Bryan W. Jones
Added 31 May 2010
Updated 31 May 2010
Type Conference
Year 2008
Where ISBI
Authors Elizabeth Jurrus, Ross T. Whitaker, Bryan W. Jones, Robert Marc, Tolga Tasdizen
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