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BMCBI
2011

Outer membrane proteins can be simply identified using secondary structure element alignment

8 years 4 months ago
Outer membrane proteins can be simply identified using secondary structure element alignment
Background: Outer membrane proteins (OMPs) are frequently found in the outer membranes of gram-negative bacteria, mitochondria and chloroplasts and have been found to play diverse functional roles. Computational discrimination of OMPs from globular proteins and other types of membrane proteins is helpful to accelerate new genome annotation and drug discovery. Results: Based on the observation that almost all OMPs consist of antiparallel b-strands in a barrel shape and that their secondary structure arrangements differ from those of other types of proteins, we propose a simple method called SSEA-OMP to identify OMPs using secondary structure element alignment. Through intensive benchmark experiments, the proposed SSEA-OMP method is better than some well-established OMP detection methods. Conclusions: The major advantage of SSEA-OMP is its good prediction performance considering its simplicity. The web server implements the method is freely accessible at http://protein.cau.edu.cn/SSEA-O...
Ren-Xiang Yan, Zhen Chen, Ziding Zhang
Added 12 May 2011
Updated 12 May 2011
Type Journal
Year 2011
Where BMCBI
Authors Ren-Xiang Yan, Zhen Chen, Ziding Zhang
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