Sciweavers

Share
CGF
2010

Pathline: A Tool For Comparative Functional Genomics

8 years 10 months ago
Pathline: A Tool For Comparative Functional Genomics
Biologists pioneering the new field of comparative functional genomics attempt to infer the mechanisms of gene regulation by looking for similarities and differences of gene activity over time across multiple species. They use three kinds of data: functional data such as gene activity measurements, pathway data that represent a series of reactions within a cellular process, and phylogenetic relationship data that describe the relatedness of species. No existing visualization tool can visually encode the biologically interesting relationships between multiple pathways, multiple genes, and multiple species. We tackle the challenge of visualizing all aspects of this comparative functional genomics dataset with a new interactive tool called Pathline. In addition to the overall characterization of the problem and design of Pathline, our contributions include two new visual encoding techniques. One is a new method for linearizing metabolic pathways that provides appropriate topological info...
Miriah D. Meyer, Bang Wong, Mark P. Styczynski, Ta
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2010
Where CGF
Authors Miriah D. Meyer, Bang Wong, Mark P. Styczynski, Tamara Munzner, Hanspeter Pfister
Comments (0)
books