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BMCBI
2011

PhyloMap: an algorithm for visualizing relationships of large sequence data sets and its application to the influenza A virus ge

10 years 3 months ago
PhyloMap: an algorithm for visualizing relationships of large sequence data sets and its application to the influenza A virus ge
Background: Results of phylogenetic analysis are often visualized as phylogenetic trees. Such a tree can typically only include up to a few hundred sequences. When more than a few thousand sequences are to be included, analyzing the phylogenetic relationships among them becomes a challenging task. The recent frequent outbreaks of influenza A viruses have resulted in the rapid accumulation of corresponding genome sequences. Currently, there are more than 7500 influenza A virus genomes in the database. There are no efficient ways of representing this huge data set as a whole, thus preventing a further understanding of the diversity of the influenza A virus genome. Results: Here we present a new algorithm, “PhyloMap”, which combines ordination, vector quantization, and phylogenetic tree construction to give an elegant representation of a large sequence data set. The use of PhyloMap on influenza A virus genome sequences reveals the phylogenetic relationships of the internal genes that...
Jiajie Zhang, Amir Madany Mamlouk, Thomas Martinet
Added 24 Aug 2011
Updated 24 Aug 2011
Type Journal
Year 2011
Where BMCBI
Authors Jiajie Zhang, Amir Madany Mamlouk, Thomas Martinetz, Suhua Chang, Jing Wang 0003, Rolf Hilgenfeld
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