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MICCAI
2005
Springer

Physiological System Identification with the Kalman Filter in Diffuse Optical Tomography

9 years 11 months ago
Physiological System Identification with the Kalman Filter in Diffuse Optical Tomography
Abstract. Diffuse optical tomography (DOT) is a noninvasive imaging technology that is sensitive to local concentration changes in oxyand deoxyhemoglobin. When applied to functional neuroimaging, DOT measures hemodynamics in the scalp and brain that reflect competing metabolic demands and cardiovascular dynamics. Separating the effects of systemic cardiovascular regulation from the local dynamics is vitally important in DOT analysis. In this paper, we use auxiliary physiological measurements such as blood pressure and heart rate within a Kalman filter framework to model physiological components in DOT. We validate the method on data from a human subject with simulated local hemodynamic responses added to the baseline physiology. The proposed method significantly improved estimates of the local hemodynamics in this test case. Cardiovascular dynamics also affect the blood oxygen dependent (BOLD) signal in functional magnetic resonance imaging (fMRI). This Kalman filter framework for DOT ...
Solomon Gilbert Diamond, Theodore J. Huppert, Vill
Added 15 Nov 2009
Updated 15 Nov 2009
Type Conference
Year 2005
Where MICCAI
Authors Solomon Gilbert Diamond, Theodore J. Huppert, Ville Kolehmainen, Maria Angela Franceschini, Jari P. Kaipio, Simon R. Arridge, David A. Boas
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