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2004

Pictorial Structures for Molecular Modeling: Interpreting Density Maps

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Pictorial Structures for Molecular Modeling: Interpreting Density Maps
X-ray crystallography is currently the most common way protein structures are elucidated. One of the most time-consuming steps in the crystallographic process is interpretation of the electron density map, a task that involves finding patterns in a three-dimensional picture of a protein. This paper describes DEFT (DEFormable Template), an algorithm using pictorial structures to build a flexible protein model from the protein's amino-acid sequence. Matching this pictorial structure into the density map is a way of automating density-map interpretation. Also described are several extensions to the pictorial structure matching algorithm necessary for this automated interpretation. DEFT is tested on a set of density maps ranging from 2 to 4
Frank DiMaio, Jude W. Shavlik, George N. Phillips
Added 31 Oct 2010
Updated 31 Oct 2010
Type Conference
Year 2004
Where NIPS
Authors Frank DiMaio, Jude W. Shavlik, George N. Phillips
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