Sciweavers

Share
ENGL
2008

Prediction of Protein-Protein Interactions Using Pairwise Alignment and Inter-Domain Linker Region

9 years 1 months ago
Prediction of Protein-Protein Interactions Using Pairwise Alignment and Inter-Domain Linker Region
One of the central problems in modern biology is to identify the complete set of interactions among the proteins in a cell. The structural interaction of proteins and their domains in networks is one of the most basic molecular mechanisms for biological cells. Structural evidence indicates that, interacting pairs of close homologs usually interact in the same way. In this article, we make use of both homology and inter-domain linker region knowledge to predict interaction between protein pairs solely by amino acid sequence information. High quality core set of 150 yeast proteins obtained from the Database of Interacting Proteins (DIP) was considered to test the accuracy of the proposed method. The strongest prediction of the method reached over 70% accuracy. These results show great potential for the proposed method.
Nazar Zaki
Added 10 Dec 2010
Updated 10 Dec 2010
Type Journal
Year 2008
Where ENGL
Authors Nazar Zaki
Comments (0)
books