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2011

PROMISCUOUS: a database for network-based drug-repositioning

8 years 1 months ago
PROMISCUOUS: a database for network-based drug-repositioning
The procedure of drug approval is time-consuming, costly and risky. Accidental findings regarding multispecificity of approved drugs led to block-busters in new indication areas. Therefore, the interest in systematically elucidating new areas of application for known drugs is rising. Furthermore, the knowledge, understanding and prediction of so-called off-target effects allow a rational approach to the understanding of side-effects. With PROMISCUOUS we provide an exhaustive set of drugs (25 000), including withdrawn or experimental drugs, annotated with drug–protein and protein–protein relationships (21 500/104 000) compiled from public resources via text and data mining including manual curation. Measures of structural similarity for drugs as well as known side-effects can be easily connected to protein–protein interactions to establish and analyse networks responsible for multi-pharmacology. This network-based approach can provide a starting point for drug-repositioning. PROM...
Joachim von Eichborn, Manuela S. Murgueitio, Mathi
Added 14 May 2011
Updated 14 May 2011
Type Journal
Year 2011
Where NAR
Authors Joachim von Eichborn, Manuela S. Murgueitio, Mathias Dunkel, Soeren Koerner, Philip E. Bourne, Robert Preissner
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