Quantitative Modeling the Saccharomyces cerevisiae FLR1 Regulatory Network Using an S-System Formalism

—We address the problem of finding a mathematical model for the genetic network regulating the stress response of the yeast Saccharomyces cerevisiae to the fungicide mancozeb. An S-system formalism was used to model the interactions of this 5 gene network. Parameter estimation was accomplished by decoupling the resulting system of nonlinear ordinary differential equations into a larger nonlinear algebraic system, and using the Levenberg-Marquardt algorithm to fit the

• Type: Journal
• Year: 2011
• Where: HISB
• Authors: Dulce Calçada, Susana Vinga, Ana T. Freitas, Arlindo L. Oliveira
• Keywords: HISB 2011, Levenberg Marquardt, Parameter Estimation, Yeast Saccharomyces Cerevisiae