Real-time estimation of cerebrospinal fluid system parameters via oscillating pressure infusion

Abstract Hydrocephalus is related to a disturbed cerebrospinal fluid (CSF) system. For diagnosis, lumbar infusion test are performed to estimate outflow conductance, Cout, and pressure volume index, PVI, of the CSF system. Infusion patterns and analysis methods used in current clinical practice are not optimized. Minimizing the investigation time with sufficient accuracy is of major clinical relevance. The aim of this study was to propose and experimentally evaluate a new method, the oscillating pressure infusion (OPI). The non-linear model of the CSF system was transformed into a linear time invariant system. Using an oscillating pressure pattern and linear system identification methods, Cout and PVI with confidence intervals, were estimated in real-time. Forty-two OPI and constant pressure infusion (CPI) investigations were performed on an experimental CSF system, designed with PVI = 25.5 ml and variable Cout. The ARX model robustly estimated Cout (mean Cout,OPI - Cout,CPI = 0.08 ll/...

• Type: Journal
• Year: 2010
• Where: MBEC
• Authors: Kennet Andersson, Ian R. Manchester, Jan Malm, Anders Eklund
• Keywords: Communications, Cout, MBEC 2010, Oscillating Pressure, Pressure