Recovering probabilities for nucleotide trimming processes for T cell receptor TRA and TRG V-J junctions analyzed with IMGT tool

Background: Nucleotides are trimmed from the ends of variable (V), diversity (D) and joining (J) genes during immunoglobulin (IG) and T cell receptor (TR) rearrangements in B cells and T cells of the immune system. This trimming is followed by addition of nucleotides at random, forming the N regions (N for nucleotides) of the V-J and V-D-J junctions. These processes are crucial for creating diversity in the immune response since the number of trimmed nucleotides and the number of added nucleotides vary in each B or T cell. IMGT

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Kevin Bleakley, Marie-Paule Lefranc, Gérard Biau
• Keywords: BMCBI 2008, Nucleotide, Sequence Analysis Tools, True Trimming Process