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BMCBI
2007

RECOVIR: An application package to automatically identify some single stranded RNA viruses using capsid protein residues that un

9 years 5 months ago
RECOVIR: An application package to automatically identify some single stranded RNA viruses using capsid protein residues that un
Background: Most single stranded RNA (ssRNA) viruses mutate rapidly to generate large number of strains having highly divergent capsid sequences. Accurate strain recognition in uncharacterized target capsid sequences is essential for epidemiology, diagnostics, and vaccine development. Strain recognition based on similarity scores between target sequences and sequences of homology matched reference strains is often time consuming and ambiguous. This is especially true if only partial target sequences are available or if different ssRNA virus families are jointly analyzed. In such cases, knowledge of residues that uniquely distinguish among known reference strains is critical for rapid and unambiguous strain identification. Conventional sequence comparisons are unable to identify such capsid residues due to high sequence divergence among the ssRNA virus reference strains. Consequently, automated general methods to reliably identify strains using strain distinguishing residues are not cu...
Dianhui Zhu, George E. Fox, Sugoto Chakravarty
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2007
Where BMCBI
Authors Dianhui Zhu, George E. Fox, Sugoto Chakravarty
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