Robust SVM-Based Biomarker Selection with Noisy Mass Spectrometric Proteomic Data

Abstract. Computational analysis of mass spectrometric (MS) proteomic data from sera is of potential relevance for diagnosis, prognosis, choice of therapy, and study of disease activity. To this aim, feature selection techniques based on machine learning can be applied for detecting potential biomarkes and biomaker patterns. A key issue concerns the interpretability and robustness of the output results given by such techniques. In this paper we propose a robust method for feature selection with MS proteomic data. The method consists of the sequentail application of a filter feature selection algorithm, RELIEF, followed by multiple runs of a wrapper feature selection technique based on support vector machines (SVM), where each run is obtained by changing the class label of one support vector. Frequencies of features selected over the runs are used to identify features which are robust with respect to perturbations of the data. This method is tested on a dataset produced by a specific MS...

• Type: Conference
• Year: 2006
• Where: EVOW
• Authors: Elena Marchiori, Connie R. Jimenez, Mikkel West-Nielsen, Niels H. H. Heegaard
• Keywords: Artificial Intelligence, EVOW 2006, Feature Selection, Feature Selection Technique, Proteomic Data