Sciweavers

Share
TCSB
2010

Rule-Based Modeling of Transcriptional Attenuation at the Tryptophan Operon

9 years 11 months ago
Rule-Based Modeling of Transcriptional Attenuation at the Tryptophan Operon
Transcriptional attenuation at E.coli’s tryptophan operon is a prime example of RNA-mediated gene regulation. In this paper, we present a discrete stochastic model for this phenomenon based on chemical reactions. Our model is compact and intelligible, due to n-ary reactions (which preclude object-centric approaches) and to rule schemas that define finite sets of chemical reactions. Stochastic simulations with our model confirm results that were previously obtained by master equations or differential equations. In addition, our approach permits to reflect mutation experiments by simple model modifications, and to re-use model components for transcriptional attenuation in other genes and organisms. Keywords. Systems biology, riboswitch, rule-based modeling languages, stochastic simulation, kappa.
Céline Kuttler, Cédric Lhoussaine, M
Added 31 Jan 2011
Updated 31 Jan 2011
Type Journal
Year 2010
Where TCSB
Authors Céline Kuttler, Cédric Lhoussaine, Mirabelle Nebut
Comments (0)
books