Signals in mRNAs that Influence the Initiation of Translation

Signals in the mRNA influence how efficiently it is translated into protein. . Previous studies have indicated that important signals are located around the initiation codon. In this study we describe a new approach to discovering these signals. This approach has been applied to 53 complete genomes or chromosomes. For the region flanking initiation codons most of the organisms fall into two groups containing previously known efficiency signals. However, we have identified several organisms with unusual signals that appear to utilise novel systems.

• Type: Conference
• Year: 2003
• Where: APBC
• Authors: Chris M. Brown, Grant H. Jacobs, Mark J. Schreiber
• Keywords: APBC 2003, APBC 2007, Important Signals, Initiation Codons, Region Flanking Initiation