Sciweavers

Share
CANDC
2008
ACM

In silico identification of the protein disulfide isomerase family from a protozoan parasite

8 years 2 months ago
In silico identification of the protein disulfide isomerase family from a protozoan parasite
Protein disulfide isomerase (PDI) enzymes are eukaryotic oxidoreductases that catalyze the correct formation of disulfide bonds during protein folding. Structurally they are characterized by the presence of functional thioredoxin-like (Trx) domains. For the protozoan parasite causative of the human amebiasis (Entamoeba histolytica), the correct formation of disulfide bonds is important for an accurate folding of its proteins, including some virulence factors. However, little is known about the enzymes involved in this mechanism. We undertook a post-genomic approach to identify the PDI family of this parasite. The genome database survey revealed a set of 11 PDI-encoding sequences with predictable protein thiol/disulfide oxidoreductase activities.
Marco A. Ramos, Rosa E. Mares, Paloma D. Maga&ntil
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2008
Where CANDC
Authors Marco A. Ramos, Rosa E. Mares, Paloma D. Magaña, Joaquín E. Ortega, Jose M. Cornejo-Bravo
Comments (0)
books