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BIOINFORMATICS
2007

Simultaneous alignment and annotation of cis-regulatory regions

8 years 11 months ago
Simultaneous alignment and annotation of cis-regulatory regions
Genomic transcriptional processes rely heavily on the combinatorial binding of transcription factors on the upstream regions of genes. Analysis and complete characterization of such ’regulatory’ regions can unlock the door to the understanding of regulatory and transcriptional mechanisms. Such analysis is usually based on the prediction of transcription factor binding site (TFBS) hits on non-coding regions. To improve the prediction of TFBS hits, phylogeneticfootprinting is generally employed. Here we propose a method that combines sequence comparison and scanning with TFBS hits to generate simultaneously annotated alignments. The hope is that simultaneous alignment and annotation can result in an improved specificity.
Abha Singh Bais, Steffen Grossmann, Martin Vingron
Added 08 Dec 2010
Updated 08 Dec 2010
Type Journal
Year 2007
Where BIOINFORMATICS
Authors Abha Singh Bais, Steffen Grossmann, Martin Vingron
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