Sciweavers

Share
CIBCB
2009
IEEE

Steady-state analysis of genetic regulatory networks modeled by nonlinear ordinary differential equations

9 years 8 months ago
Steady-state analysis of genetic regulatory networks modeled by nonlinear ordinary differential equations
Although Ordinary Differential Equations (ODEs) have been used to model Genetic Regulatory Networks (GRNs) in many previous works, their steady-state behaviors are not well studied. However, a phenotype corresponds to a steadystate gene expression pattern and steady-state analysis of GRNs can provide valuable information on the stability of the GRNs, insights into cellular regulatory mechanisms underlying disease development as well as possible interventions for disease control. In this study, the steady-state behaviors of the nonlinear GRN models are analyzed based on time series data. The steady-state solutions and stability of nonlinear GRNs including polynomial model, sigmoidal model and S-system model are discussed in details.
Haixin Wang, Lijun Qian, Edward R. Dougherty
Added 08 Nov 2010
Updated 08 Nov 2010
Type Conference
Year 2009
Where CIBCB
Authors Haixin Wang, Lijun Qian, Edward R. Dougherty
Comments (0)
books