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BMCBI
2006

Systematic assignment of thermodynamic constraints in metabolic network models

11 years 8 months ago
Systematic assignment of thermodynamic constraints in metabolic network models
Background: The availability of genome sequences for many organisms enabled the reconstruction of several genome-scale metabolic network models. Currently, significant efforts are put into the automated reconstruction of such models. For this, several computational tools have been developed that particularly assist in identifying and compiling the organism-specific lists of metabolic reactions. In contrast, the last step of the model reconstruction process, which is the definition of the thermodynamic constraints in terms of reaction directionalities, still needs to be done manually. No computational method exists that allows for an automated and systematic assignment of reaction directions in genome-scale models. Results: We present an algorithm that
Anne Kümmel, Sven Panke, Matthias Heinemann
Added 10 Dec 2010
Updated 10 Dec 2010
Type Journal
Year 2006
Where BMCBI
Authors Anne Kümmel, Sven Panke, Matthias Heinemann
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