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GECCO
2005
Springer

There's more to a model than code: understanding and formalizing in silico modeling experience

11 years 9 hour ago
There's more to a model than code: understanding and formalizing in silico modeling experience
Mapping biology into computation has both a domain specific aspect – biological theory – and a methodological aspect – model development. Computational modelers have implicit knowledge that guides modeling in many ways but this knowledge is rarely communicated. We review the challenge of biological complexity and current practices in modeling genetic regulatory networks with the aim of understanding characteristics of the in silico modeling process and proposing directions for future improvements. Specifically, we contend that the modeling of complex biological systems can be made more efficient and more effective by the use of structured methodologies incorporating experience about modeling algorithms and implementation. We suggest that an appropriate formalism is Complex Systems Patterns, adopted from Design Patterns in software engineering. First steps towards building community resources for such patterns are described. Categories and Subject Descriptors D.2 [Software] D.2.1...
Janet Wiles, Nicholas Geard, James Watson, Kai Wil
Added 27 Jun 2010
Updated 27 Jun 2010
Type Conference
Year 2005
Where GECCO
Authors Janet Wiles, Nicholas Geard, James Watson, Kai Willadsen, John Mattick, Daniel Bradley, Jennifer Hallinan
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