Three Dimensional Visualization of Proteins in Cellular Interactions

In researching the communication mechanisms between cells of the immune system, visualization of proteins in three dimensions can be used to determine which proteins are capable of interacting with one another at a given time by showing their spatial colocality. Volume data sets are created using digital confocal immunofluorescence microscopy. A variety of visualization approaches are then used to examine the interactions. These include volume rendering, isosurface extraction, and virtual reality. Based on our experiences, we have concluded that no single one of these approaches provides a complete solution for visualizing biological data. However, in combination, their respective strengths complement one another to provide an understanding of the data.

• Type: Conference
• Year: 1996
• Where: VISUALIZATION
• Authors: Colin R. F. Monks, Patricia Crossno, George S. Davidson, Constantine J. Pavlakos, Abraham Kupfer, Cláudio T. Silva, Brian N. Wylie
• Keywords: Confocal Immunofluorescence Microscopy, Respective Strengths Complement, Visualization, VISUALIZATION 1996, Volume Data Sets