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JELIA
2004
Springer

Towards a Logical Analysis of Biochemical Pathways

13 years 9 months ago
Towards a Logical Analysis of Biochemical Pathways
Biochemical pathways or networks are generic representations used to model many different types of complex functional and physical interactions in biological systems. Models based on experimental results are often incomplete, e.g., reactions may be missing and only some products are observed. In such cases, one would like to reason about incomplete network representations and propose candidate hypotheses, which when represented as additional reactions, substrates, products, would complete the network and provide causal explanations for the existing observations. In this paper, we provide a logical model of biochemical pathways and show how abductive hypothesis generation may be used to provide additional information about incomplete pathways. Hypothesis generation is achieved using weakest and strongest necessary conditions which represent these incomplete biochemical pathways and explain observations about the functional and physical interactions being modeled. The techniques are demo...
Patrick Doherty, Steve Kertes, Martin Magnusson, A
Added 02 Jul 2010
Updated 02 Jul 2010
Type Conference
Year 2004
Where JELIA
Authors Patrick Doherty, Steve Kertes, Martin Magnusson, Andrzej Szalas
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