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BMCBI
2010

Trees on networks: resolving statistical patterns of phylogenetic similarities among interacting proteins

10 years 2 months ago
Trees on networks: resolving statistical patterns of phylogenetic similarities among interacting proteins
Background: Phylogenies capture the evolutionary ancestry linking extant species. Correlations and similarities among a set of species are mediated by and need to be understood in terms of the phylogenic tree. In a similar way it has been argued that biological networks also induce correlations among sets of interacting genes or their protein products. Results: We develop suitable statistical resampling schemes that can incorporate these two potential sources of correlation into a single inferential framework. To illustrate our approach we apply it to protein interaction data in yeast and investigate whether the phylogenetic trees of interacting proteins in a panel of yeast species are more similar than would be expected by chance. Conclusions: While we find only negligible evidence for such increased levels of similarities, our statistical approach allows us to resolve the previously reported contradictory results on the levels of co-evolution induced by protein-protein interactions....
William P. Kelly, Michael P. H. Stumpf
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2010
Where BMCBI
Authors William P. Kelly, Michael P. H. Stumpf
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