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2008

Visualizing Genome Expression and Regulatory Network Dynamics in Genomic and Metabolic Context

9 years 1 months ago
Visualizing Genome Expression and Regulatory Network Dynamics in Genomic and Metabolic Context
DNA microarrays are used to measure the expression levels of thousands of genes simultaneously. In a time series experiment, the gene expressions are measured as a function of time. We present an application for integrated visualization of genome expression and network dynamics in both regulatory networks and metabolic pathways. Integration of these two levels of cellular processes is necessary, since it provides the link between the measurements at the transcriptional level (gene expression levels approximated from microarray data) and the phenotype (the observable characteristics of an organism) at the functional and behavioral level. The integration requires visualization approaches besides traditional clustering and statistical analysis methods. Our application can (i) visualize the data from time series experiments in the context of a regulatory network and KEGG metabolic pathways; (ii) identify and visualize active regulatory subnetworks from the gene expression data; (iii) perf...
Michel A. Westenberg, Sacha A. F. T. van Hijum, Os
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2008
Where CGF
Authors Michel A. Westenberg, Sacha A. F. T. van Hijum, Oscar P. Kuipers, J. B. T. M. Roerdink
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