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BMCBI
2006
171views more  BMCBI 2006»
13 years 5 months ago
The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies
Background: Intensity values measured by Affymetrix microarrays have to be both normalized, to be able to compare different microarrays by removing non-biological variation, and s...
Roel G. W. Verhaak, Frank J. T. Staal, Peter J. M....
BMCBI
2010
152views more  BMCBI 2010»
13 years 5 months ago
Comparative study of discretization methods of microarray data for inferring transcriptional regulatory networks
Background: Microarray data discretization is a basic preprocess for many algorithms of gene regulatory network inference. Some common discretization methods in informatics are us...
Yong Li, Lili Liu, Xi Bai, Hua Cai, Wei Ji, Dianji...
BMCBI
2010
190views more  BMCBI 2010»
13 years 5 months ago
Sample size and statistical power considerations in high-dimensionality data settings: a comparative study of classification alg
Background: Data generated using `omics' technologies are characterized by high dimensionality, where the number of features measured per subject vastly exceeds the number of...
Yu Guo, Armin Graber, Robert N. McBurney, Raji Bal...
BMCBI
2004
128views more  BMCBI 2004»
13 years 4 months ago
Comparing transformation methods for DNA microarray data
Background: When DNA microarray data are used for gene clustering, genotype/phenotype correlation studies, or tissue classification the signal intensities are usually transformed ...
Helene H. Thygesen, Aeilko H. Zwinderman
BMCBI
2007
149views more  BMCBI 2007»
13 years 5 months ago
Robust imputation method for missing values in microarray data
Background: When analyzing microarray gene expression data, missing values are often encountered. Most multivariate statistical methods proposed for microarray data analysis canno...
Dankyu Yoon, Eun-Kyung Lee, Taesung Park