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» A Framework for Modeling DNA Based Molecular Systems
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JCB
1998
129views more  JCB 1998»
13 years 5 months ago
A Sticker-Based Model for DNA Computation
We introduce a new model of molecular computation that we call the sticker model. Like many previous proposals it makes use of DNA strands as the physical substrate in which infor...
Sam T. Roweis, Erik Winfree, Richard Burgoyne, Nic...
BMCBI
2007
159views more  BMCBI 2007»
13 years 5 months ago
Computational genes: a tool for molecular diagnosis and therapy of aberrant mutational phenotype
Background: A finite state machine manipulating information-carrying DNA strands can be used to perform autonomous molecular-scale computations at the cellular level. Results: We ...
Israel Mark Martínez-Pérez, Gong Zha...
BMCBI
2007
130views more  BMCBI 2007»
13 years 5 months ago
A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression da
Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, th...
Reuben Thomas, Carlos J. Paredes, Sanjay Mehrotra,...
CLEIEJ
2006
88views more  CLEIEJ 2006»
13 years 5 months ago
A Stochastic Concurrent Constraint Based Framework to Model and Verify Biological Systems
Concurrent process calculi are powerful formalisms for modelling concurrent systems. The mathematical style underlying process calculi allow to both model and verify properties of...
Carlos Olarte, Camilo Rueda
JCC
2008
138views more  JCC 2008»
13 years 5 months ago
Circular dichroism enhancement in large DNA aggregates simulated by a generalized oscillator model
Abstract: An increased circular dichroism (CD) signal of large molecular aggregates formed upon DNA condensation was observed a long time ago, and is often referred to as w-CD. The...
Valery Andrushchenko, Petr Bour