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» A Study of the Role of Single Node Mutation in Genetic Progr...
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BMCBI
2007
145views more  BMCBI 2007»
13 years 5 months ago
Genome bioinformatic analysis of nonsynonymous SNPs
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
David F. Burke, Catherine L. Worth, Eva-Maria Prie...
BMCBI
2010
151views more  BMCBI 2010»
13 years 5 months ago
CCRaVAT and QuTie - enabling analysis of rare variants in large-scale case control and quantitative trait association studies
Background: Genome-wide association studies have been successful in finding common variants influencing common traits. However, these associations only account for a fraction of t...
Robert Lawrence, Aaron G. Day-Williams, Katherine ...
BMCBI
2010
108views more  BMCBI 2010»
13 years 5 months ago
Confronting two-pair primer design for enzyme-free SNP genotyping based on a genetic algorithm
Background: Polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method produces allelespecific DNA bands of different lengths by adding four designed primers an...
Cheng-Hong Yang, Yu-Huei Cheng, Li-Yeh Chuang, Hsu...
GECCO
2006
Springer
161views Optimization» more  GECCO 2006»
13 years 8 months ago
An empirical investigation of how and why neutrality affects evolutionary search
The effects of neutrality on evolutionary search have been considered in a number of interesting studies, the results of which, however, have been contradictory. Some researchers ...
Edgar Galván López, Riccardo Poli