Sciweavers

210 search results - page 4 / 42
» A functional hierarchical organization of the protein sequen...
Sort
View
BMCBI
2004
177views more  BMCBI 2004»
13 years 5 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
NAR
1998
161views more  NAR 1998»
13 years 5 months ago
Touring protein fold space with Dali/FSSP
The FSSP database and its new supplement, the Dali Domain Dictionary, present a continuously updated classification of all known 3D protein structures. The classification is deriv...
Liisa Holm, Chris Sander
BMCBI
2008
200views more  BMCBI 2008»
13 years 5 months ago
Defining functional distances over Gene Ontology
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
BMCBI
2010
160views more  BMCBI 2010»
13 years 5 months ago
Identification of functional hubs and modules by converting interactome networks into hierarchical ordering of proteins
Background: Protein-protein interactions play a key role in biological processes of proteins within a cell. Recent high-throughput techniques have generated protein-protein intera...
Young-Rae Cho, Aidong Zhang
MCS
2010
Springer
13 years 10 months ago
An Experimental Comparison of Hierarchical Bayes and True Path Rule Ensembles for Protein Function Prediction
Abstract. The computational genome-wide annotation of gene functions requires the prediction of hierarchically structured functional classes and can be formalized as a multiclass, ...
Matteo Re, Giorgio Valentini