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COMPLIFE
2005
Springer
13 years 11 months ago
The Architecture of a Proteomic Network in the Yeast
Abstract. We describe an approach to clustering the yeast protein-protein interaction network in order to identify functional modules, groups of proteins forming multi-protein comp...
Emad Ramadan, Christopher Osgood, Alex Pothen
BMCBI
2002
101views more  BMCBI 2002»
13 years 5 months ago
Total sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleases
Background: Total sequence decomposition, using the web-based MASIA tool, identifies areas of conservation in aligned protein sequences. By structurally annotating these motifs, t...
Catherine H. Schein, Numan Özgün, Tadahi...
ALMOB
2006
109views more  ALMOB 2006»
13 years 5 months ago
A novel functional module detection algorithm for protein-protein interaction networks
Background: The sparse connectivity of protein-protein interaction data sets makes identification of functional modules challenging. The purpose of this study is to critically eva...
Woochang Hwang, Young-Rae Cho, Aidong Zhang, Mural...
BMCBI
2008
82views more  BMCBI 2008»
13 years 6 months ago
Studying the functional conservation of cis-regulatory modules and their transcriptional output
Background: Cis-regulatory modules (CRMs) are distinct, genomic regions surrounding the target gene that can independently activate the promoter to drive transcription. The activa...
Denis C. Bauer, Timothy L. Bailey
BMCBI
2008
83views more  BMCBI 2008»
13 years 6 months ago
Prioritization of gene regulatory interactions from large-scale modules in yeast
Background: The identification of groups of co-regulated genes and their transcription factors, called transcriptional modules, has been a focus of many studies about biological s...
Ho-Joon Lee, Thomas Manke, Ricardo Bringas, Martin...