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» A multistep bioinformatic approach detects putative regulato...
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BMCBI
2011
8 years 9 months ago
A mutation degree model for the identification of transcriptional regulatory elements
Background: Current approaches for identifying transcriptional regulatory elements are mainly via the combination of two properties, the evolutionary conservation and the overrepr...
Changqing Zhang, Jin Wang, Xu Hua, Jinggui Fang, H...
BMCBI
2005
169views more  BMCBI 2005»
9 years 5 months ago
MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes
Background: Cis-regulatory modules are combinations of regulatory elements occurring in close proximity to each other that control the spatial and temporal expression of genes. Th...
Voichita D. Marinescu, Isaac S. Kohane, Alberto Ri...
BMCBI
2005
104views more  BMCBI 2005»
9 years 5 months ago
An integrated approach of immunogenomics and bioinformatics to identify new Tumor Associated Antigens (TAA) for mammary cancer i
Background: Neoplastic transformation is a multistep process in which distinct gene products of specific cell regulatory pathways are involved at each stage. Identification of ove...
Federica Cavallo, Annalisa Astolfi, Manuela Iezzi,...
IMSCCS
2006
IEEE
9 years 11 months ago
Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs
Background: As more and more genomes are sequenced, comparative genomics approaches provide a methodology for identifying conserved regulatory elements that may be involved in gen...
Linyong Mao, W. Jim Zheng
BMCBI
2007
126views more  BMCBI 2007»
9 years 5 months ago
Multiple non-collinear TF-map alignments of promoter regions
Background: The analysis of the promoter sequence of genes with similar expression patterns is a basic tool to annotate common regulatory elements. Multiple sequence alignments ar...
Enrique Blanco, Roderic Guigó, Xavier Messe...
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