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BMCBI
2005
141views more  BMCBI 2005»
13 years 4 months ago
A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models
Background: G- Protein coupled receptors (GPCRs) comprise the largest group of eukaryotic cell surface receptors with great pharmacological interest. A broad range of native ligan...
Nikolaos G. Sgourakis, Pantelis G. Bagos, Panagiot...
BMCBI
2005
87views more  BMCBI 2005»
13 years 4 months ago
Efficient decoding algorithms for generalized hidden Markov model gene finders
Background: The Generalized Hidden Markov Model (GHMM) has proven a useful framework for the task of computational gene prediction in eukaryotic genomes, due to its flexibility an...
William H. Majoros, Mihaela Pertea, Arthur L. Delc...
BMCBI
2006
102views more  BMCBI 2006»
13 years 5 months ago
Protein secondary structure prediction for a single-sequence using hidden semi-Markov models
Background: The accuracy of protein secondary structure prediction has been improving steadily towards the 88% estimated theoretical limit. There are two types of prediction algor...
Zafer Aydin, Yucel Altunbasak, Mark Borodovsky
BMCBI
2010
123views more  BMCBI 2010»
13 years 5 months ago
Decoding HMMs using the k best paths: algorithms and applications
Background: Traditional algorithms for hidden Markov model decoding seek to maximize either the probability of a state path or the number of positions of a sequence assigned to th...
Daniel G. Brown 0001, Daniil Golod
JCSS
2007
116views more  JCSS 2007»
13 years 4 months ago
The most probable annotation problem in HMMs and its application to bioinformatics
Hidden Markov models (HMMs) are often used for biological sequence annotation. Each sequence feature is represented by a collection of states with the same label. In annotating a ...
Brona Brejová, Daniel G. Brown 0001, Tom&aa...