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BMCBI
2010
86views more  BMCBI 2010»
13 years 5 months ago
A novel approach to simulate gene-environment interactions in complex diseases
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with lar...
Roberto Amato, Michele Pinelli, Daniel D'Andrea, G...
IPMI
2009
Springer
14 years 6 months ago
Multivariate High-Dimensional Cortical Folding Analysis, Combining Complexity and Shape, in Neonates with Congenital Heart Disea
The paper presents a novel statistical framework for cortical folding pattern analysis that relies on a rich multivariate descriptor of folding patterns in a region of interest (RO...
Suyash P. Awate, Paul A. Yushkevich, Zhuang Song, ...
ISBI
2006
IEEE
14 years 6 months ago
Cancer disease: integrative modelling approaches
Cancer is a complex disease in which a variety of phenomena interact over a wide range of spatial and temporal scales. In this article a theoretical framework will be introduced t...
Helen M. Byrne, Markus R. Owen, Tomas Alarcó...
BMCBI
2010
108views more  BMCBI 2010»
13 years 5 months ago
A genetic ensemble approach for gene-gene interaction identification
Background: It has now become clear that gene-gene interactions and gene-environment interactions are ubiquitous and fundamental mechanisms for the development of complex diseases...
Pengyi Yang, Joshua W. K. Ho, Albert Y. Zomaya, Bi...
GECCO
2005
Springer
127views Optimization» more  GECCO 2005»
13 years 10 months ago
Sufficiency verification of HIV-1 pathogenesis based on multi-agent simulation
Researchers of HIV-1 are today, still unable to determine exactly the biological mechanisms that cause AIDS. Various mechanisms have been hypothesized and their existences have be...
Zaiyi Guo, Hann Kwang Han, Joc Cing Tay