77 search results - page 1 / 16 » A structural keystone for drug design |
JIB
2006
13 years 4 months ago
2006
3D-structures of proteins and potential ligands are the cornerstones of rational drug design. The first brick to build upon is selecting a protein target and finding out whether b...
NAR
2006
13 years 4 months ago
2006
DrugBank is a unique bioinformatics/cheminformatics resource that combines detailed drug (i.e. chemical)data withcomprehensive drug target (i.e.protein) information. The database ...
BMCBI
2010
12 years 11 months ago
2010
Background: The functional and structural characterisation of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design. The main inter...
ALGORITHMICA
1999
13 years 4 months ago
1999
Abstract. The rational approach to pharmaceutical drug design begins with an investigation of the relationship between chemical structure and biological activity. Information gaine...
EDBT
2012
ACM
11 years 7 months ago
2012
ACM
Increased availability of large repositories of chemical compounds has created new challenges and opportunities for the application of data-mining and indexing techniques to probl...