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BMCBI
2008
128views more  BMCBI 2008»
13 years 6 months ago
HAPSIMU: a genetic simulation platform for population-based association studies
Background: Population structure is an important cause leading to inconsistent results in population-based association studies (PBAS) of human diseases. Various statistical method...
Feng Zhang, Jianfeng Liu, Jie Chen, Hong-Wen Deng
BMCBI
2008
138views more  BMCBI 2008»
13 years 6 months ago
Inference of haplotypic phase and missing genotypes in polyploid organisms and variable copy number genomic regions
Background: The power of haplotype-based methods for association studies, identification of regions under selection, and ancestral inference, is well-established for diploid organ...
Shu-Yi Su, Jonathan White, David J. Balding, Lachl...
BMCBI
2006
116views more  BMCBI 2006»
13 years 6 months ago
Whole genome association mapping by incompatibilities and local perfect phylogenies
Background: With current technology, vast amounts of data can be cheaply and efficiently produced in association studies, and to prevent data analysis to become the bottleneck of ...
Thomas Mailund, Søren Besenbacher, Mikkel H...
BMCBI
2007
131views more  BMCBI 2007»
13 years 6 months ago
ISHAPE: new rapid and accurate software for haplotyping
Background: We have developed a new haplotyping program based on the combination of an iterative multiallelic EM algorithm (IEM), bootstrap resampling and a pseudo Gibbs sampler. ...
Olivier Delaneau, Cédric Coulonges, Pierre-...
ACMSE
2006
ACM
14 years 4 days ago
Framework design using function generalization: a binary tree traversal case study
A software framework is a technology that enables software reuse, potentially yielding rich dividends but requiring significant longterm investment. However, a framework is not a ...
H. Conrad Cunningham, Yi Liu, Pallavi Tadepalli