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» An Evolutionary Approach for Molecular Docking
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JCB
2000
137views more  JCB 2000»
13 years 5 months ago
NOTUNG: A Program for Dating Gene Duplications and Optimizing Gene Family Trees
Large scale gene duplication is a major force driving the evolution of genetic functional innovation. Whole genome duplications are widely believed to have played an important rol...
Kevin Chen, Dannie Durand, Martin Farach-Colton
BMCBI
2008
96views more  BMCBI 2008»
13 years 5 months ago
Novel methodology for construction and pruning of quasi-median networks
Background: Visualising the evolutionary history of a set of sequences is a challenge for molecular phylogenetics. One approach is to use undirected graphs, such as median network...
Sarah C. Ayling, Terence A. Brown
BIOINFORMATICS
2010
138views more  BIOINFORMATICS 2010»
13 years 5 months ago
Robust unmixing of tumor states in array comparative genomic hybridization data
Motivation: Tumorigenesis is an evolutionary process by which tumor cells acquire sequences of mutations leading to increased growth, invasiveness, and eventually metastasis. It i...
David Tolliver, Charalampos E. Tsourakakis, Ayshwa...
EVOW
2007
Springer
13 years 11 months ago
Modeling the Shoot Apical Meristem in A. thaliana : Parameter Estimation for Spatial Pattern Formation
Understanding the self-regulatory mechanisms controlling the spatial and temporal structure of multicellular organisms represents one of the major challenges in molecular biology. ...
Tim Hohm, Eckart Zitzler
BMCBI
2004
126views more  BMCBI 2004»
13 years 5 months ago
A probabilistic model for the evolution of RNA structure
Background: For the purposes of finding and aligning noncoding RNA gene- and cis-regulatory elements in multiple-genome datasets, it is useful to be able to derive multi-sequence ...
Ian Holmes