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» An SVM-based system for predicting protein subnuclear locali...
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BMCBI
2008
100views more  BMCBI 2008»
13 years 5 months ago
Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen p
Background: T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherap...
Guanglan Zhang, Asif M. Khan, Kellathur N. Sriniva...
BMCBI
2005
150views more  BMCBI 2005»
13 years 5 months ago
Discover protein sequence signatures from protein-protein interaction data
Background: The development of high-throughput technologies such as yeast two-hybrid systems and mass spectrometry technologies has made it possible to generate large protein-prot...
Jianwen Fang, Ryan J. Haasl, Yinghua Dong, Gerald ...
CEC
2005
IEEE
13 years 11 months ago
A genetic algorithm for energy minimization in bio-molecular systems
Energy minimization algorithms for bio-molecular systems are critical to applications such as the prediction of protein folding. Conventional energy minimization methods such as th...
Xiaochun Weng, Lutz Hamel, Lenore M. Martin, Joan ...
JCB
2007
144views more  JCB 2007»
13 years 5 months ago
Statistical Estimation of Statistical Mechanical Models: Helix-Coil Theory and Peptide Helicity Prediction
Analysis of biopolymer sequences and structures generally adopts one of two approaches: use of detailed biophysical theoretical models of the system with experimentally-determined...
Scott C. Schmidler, Joseph E. Lucas, Terrence G. O...
BMCBI
2011
13 years 10 days ago
OrthoInspector: comprehensive orthology analysis and visual exploration
Background: The accurate determination of orthology and inparalogy relationships is essential for comparative sequence analysis, functional gene annotation and evolutionary studie...
Benjamin Linard, Julie D. Thompson, Olivier Poch, ...