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» An evolutionary progressive multiple sequence alignment
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BMCBI
2008
178views more  BMCBI 2008»
13 years 5 months ago
A discriminative method for protein remote homology detection and fold recognition combining Top-n-grams and latent semantic ana
Background: Protein remote homology detection and fold recognition are central problems in bioinformatics. Currently, discriminative methods based on support vector machine (SVM) ...
Bin Liu, Xiaolong Wang, Lei Lin, Qiwen Dong, Xuan ...
BMCBI
2007
113views more  BMCBI 2007»
13 years 5 months ago
Statistical power of phylo-HMM for evolutionarily conserved element detection
Background: An important goal of comparative genomics is the identification of functional elements through conservation analysis. Phylo-HMM was recently introduced to detect conse...
Xiaodan Fan, Jun Zhu, Eric E. Schadt, Jun S. Liu
ICML
2004
IEEE
14 years 6 months ago
Support vector machine learning for interdependent and structured output spaces
Learning general functional dependencies is one of the main goals in machine learning. Recent progress in kernel-based methods has focused on designing flexible and powerful input...
Ioannis Tsochantaridis, Thomas Hofmann, Thorsten J...
BMCBI
2008
125views more  BMCBI 2008»
13 years 5 months ago
A fast algorithm for the multiple genome rearrangement problem with weighted reversals and transpositions
Background: Due to recent progress in genome sequencing, more and more data for phylogenetic reconstruction based on rearrangement distances between genomes become available. Howe...
Martin Bader, Mohamed Ibrahim Abouelhoda, Enno Ohl...
BMCBI
2008
150views more  BMCBI 2008»
13 years 5 months ago
MOSAIC: an online database dedicated to the comparative genomics of bacterial strains at the intra-species level
Background: The recent availability of complete sequences for numerous closely related bacterial genomes opens up new challenges in comparative genomics. Several methods have been...
Hélène Chiapello, Annie Gendrault, C...