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IJBRA
2010
108views more  IJBRA 2010»
13 years 2 months ago
Assessing and improving the accuracy of detecting protein adaptation with the TreeSAAP analytical software
The TreeSAAP software has been successfully used in a variety of protein studies for identifying and characterizing adaptation in terms of shifts in the physicochemical properties ...
David A. McClellan, David D. Ellison
BMCBI
2005
152views more  BMCBI 2005»
13 years 4 months ago
Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Markus Wistrand, Erik L. L. Sonnhammer
BMCBI
2010
118views more  BMCBI 2010»
13 years 4 months ago
Bacillus anthracis genome organization in light of whole transcriptome sequencing
Emerging knowledge of whole prokaryotic transcriptomes could validate a number of theoretical concepts introduced in the early days of genomics. What are the rules connecting gene...
Jeffrey Martin, Wenhan Zhu, Karla D. Passalacqua, ...
BMCBI
2010
103views more  BMCBI 2010»
13 years 4 months ago
Nonparametric methods for the analysis of single-color pathogen microarrays
Background: The analysis of oligonucleotide microarray data in pathogen surveillance and discovery is a challenging task. Target template concentration, nucleic acid integrity, an...
Omar J. Jabado, Sean Conlan, P. Lan Quan, Jeffrey ...