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CMSB
2008
Springer
13 years 6 months ago
Automatic Complexity Analysis and Model Reduction of Nonlinear Biochemical Systems
Kinetic models for biochemical systems often comprise a large amount of coupled differential equations with species concentrations varying on different time scales. In this paper w...
Dirk Lebiedz, Dominik Skanda, Marc Fein
HYBRID
2007
Springer
13 years 8 months ago
Qualitative Analysis of Nonlinear Biochemical Networks with Piecewise-Affine Functions
Abstract. Nonlinearities and the lack of accurate quantitative information considerably hamper modeling and system analysis of biochemical networks. Here we propose a procedure for...
M. W. J. M. Musters, Hidde de Jong, P. P. J. van d...
BIOCOMP
2010
13 years 2 months ago
A Model Reduction Technique for Stochastic Biochemical Kinetics
Abstract-- Modeling the intermolecular reactions in a single cell is a critical problem in computational biology. Biochemical reaction systems often involve species in both low and...
Silvana Ilie, Ekaterina Kudashkina
CEC
2010
IEEE
12 years 11 months ago
Parameter estimation with term-wise decomposition in biochemical network GMA models by hybrid regularized Least Squares-Particle
High-throughput analytical techniques such as nuclear magnetic resonance, protein kinase phosphorylation, and mass spectroscopic methods generate time dense profiles of metabolites...
Prospero C. Naval, Luis G. Sison, Eduardo R. Mendo...
BMCBI
2008
121views more  BMCBI 2008»
13 years 4 months ago
Modularization of biochemical networks based on classification of Petri net t-invariants
Background: Structural analysis of biochemical networks is a growing field in bioinformatics and systems biology. The availability of an increasing amount of biological data from ...
Eva Grafahrend-Belau, Falk Schreiber, Monika Heine...