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» Bifurcation into Functional Niches in Adaptation
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BMCBI
2002
81views more  BMCBI 2002»
13 years 5 months ago
Species-specific protein sequence and fold optimizations
Background: An organism's ability to adapt to its particular environmental niche is of fundamental importance to its survival and proliferation. In the largest study of its k...
Michel Dumontier, Katerina Michalickova, Christoph...
ICNC
2005
Springer
13 years 10 months ago
Coevolutionary Genetic Algorithms to Simulate the Immune System's Gene Libraries Evolution
Two binary-encoded models describing some aspects of the coevolution between an artificial immune system and a set of antigens have been proposed and analyzed. The first model ha...
Grazziela Patrocinio Figueredo, Luís Alfred...
BMCBI
2011
12 years 8 months ago
Dissecting protein loops with a statistical scalpel suggests a functional implication of some structural motifs
Background: One of the strategies for protein function annotation is to search particular structural motifs that are known to be shared by proteins with a given function. Results:...
Leslie Regad, Juliette Martin, Anne-Claude Camprou...
TEC
2002
133views more  TEC 2002»
13 years 4 months ago
Learning and optimization using the clonal selection principle
The clonal selection principle is used to explain the basic features of an adaptive immune response to an antigenic stimulus. It establishes the idea that only those cells that rec...
Leandro Nunes de Castro, Fernando J. Von Zuben