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BMCBI
2007
114views more  BMCBI 2007»
13 years 5 months ago
Combination of scoring schemes for protein docking
Background: Docking algorithms are developed to predict in which orientation two proteins are likely to bind under natural conditions. The currently used methods usually consist o...
Philipp Heuser, Dietmar Schomburg
AIPS
2010
13 years 8 months ago
When Policies Can Be Trusted: Analyzing a Criteria to Identify Optimal Policies in MDPs with Unknown Model Parameters
Computing a good policy in stochastic uncertain environments with unknown dynamics and reward model parameters is a challenging task. In a number of domains, ranging from space ro...
Emma Brunskill
BMCBI
2008
111views more  BMCBI 2008»
13 years 5 months ago
Molecular docking studies of dithionitrobenzoic acid and its related compounds to protein disulfide isomerase: computational scr
Background: Entry of HIV-1 into human lymphoid requires activities of viral envelope glycoproteins gp120 and gp41, and two host-cell proteins, the primary receptor CD4 and a chemo...
Uthaman Gowthaman, Mannu Jayakanthan, Durai Sundar
BMCBI
2008
106views more  BMCBI 2008»
13 years 5 months ago
Identification of hot-spot residues in protein-protein interactions by computational docking
Background: The study of protein-protein interactions is becoming increasingly important for biotechnological and therapeutic reasons. We can define two major areas therein: the s...
Solène Grosdidier, Juan Fernández-Re...
BMCBI
2006
98views more  BMCBI 2006»
13 years 5 months ago
Optimised amino acid specific weighting factors for unbound protein docking
Background: One of the most challenging aspects of protein-protein docking is the inclusion of flexibility into the docking procedure. We developed a postfilter where the grid-rep...
Philipp Heuser, Dietmar Schomburg