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» Cancer disease: integrative modelling approaches
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BMCBI
2010
84views more  BMCBI 2010»
13 years 5 months ago
An integrated analysis of molecular aberrations in NCI-60 cell lines
Background: Cancer is a complex disease where various types of molecular aberrations drive the development and progression of malignancies. Large-scale screenings of multiple type...
Chen-Hsiang Yeang
EDBTW
2006
Springer
13 years 9 months ago
An Integrated Platform for Analyzing Molecular-Biological Data Within Clinical Studies
To investigate molecular-biological causes and effects of diseases and their therapies it becomes increasingly important to combine data from clinical trials with high volumes of e...
Toralf Kirsten, Jörg Lange, Erhard Rahm
BMCBI
2005
112views more  BMCBI 2005»
13 years 5 months ago
Towards precise classification of cancers based on robust gene functional expression profiles
Background: Development of robust and efficient methods for analyzing and interpreting high dimension gene expression profiles continues to be a focus in computational biology. Th...
Zheng Guo, Tianwen Zhang, Xia Li, Qi Wang, Jianzhe...
KES
2008
Springer
13 years 4 months ago
Classification of Sporadic and BRCA1 Ovarian Cancer Based on a Genome-Wide Study of Copy Number Variations
Abstract. Motivation: Although studies have shown that genetic alterations are causally involved in numerous human diseases, still not much is known about the molecular mechanisms ...
Anneleen Daemen, Olivier Gevaert, Karin Leunen, Va...
BMCBI
2010
122views more  BMCBI 2010»
13 years 5 months ago
Ovarian cancer classification based on dimensionality reduction for SELDI-TOF data
Background: Recent advances in proteomics technologies such as SELDI-TOF mass spectrometry has shown promise in the detection of early stage cancers. However, dimensionality reduc...
Kai-Lin Tang, Tong-Hua Li, Wen-Wei Xiong, Kai Chen