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BIOINFORMATICS
2012
11 years 7 months ago
Causal reasoning on biological networks: interpreting transcriptional changes
d Abstract) Leonid Chindelevitch1 , Daniel Ziemek1, , Ahmed Enayetallah2 , Ranjit Randhawa1 , Ben Sidders3 , Christoph Brockel4 , and Enoch Huang1 1 Computational Sciences Center o...
Leonid Chindelevitch, Daniel Ziemek, Ahmed Enayeta...
BMCBI
2007
122views more  BMCBI 2007»
13 years 4 months ago
Dissecting complex transcriptional responses using pathway-level scores based on prior information
Background: The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathway...
Harmen J. Bussemaker, Lucas D. Ward, André ...
BMCBI
2005
189views more  BMCBI 2005»
13 years 4 months ago
Quantitative inference of dynamic regulatory pathways via microarray data
Background: The cellular signaling pathway (network) is one of the main topics of organismic investigations. The intracellular interactions between genes in a signaling pathway ar...
Wen-Chieh Chang, Chang-Wei Li, Bor-Sen Chen
BMCBI
2011
12 years 8 months ago
RegNetB: Predicting Relevant Regulator-Gene Relationships in Localized Prostate Tumor Samples
Background: A central question in cancer biology is what changes cause a healthy cell to form a tumor. Gene expression data could provide insight into this question, but it is dif...
Angel Alvarez, Peter J. Woolf
BMCBI
2007
152views more  BMCBI 2007»
13 years 5 months ago
Difference-based clustering of short time-course microarray data with replicates
Background: There are some limitations associated with conventional clustering methods for short time-course gene expression data. The current algorithms require prior domain know...
Jihoon Kim, Ju Han Kim