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» ChemProt: a disease chemical biology database
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NAR
2011
216views Computer Vision» more  NAR 2011»
12 years 7 months ago
ChemProt: a disease chemical biology database
Systems pharmacology is an emergent area that studies drug action across multiple scales of complexity, from molecular and cellular to tissue and organism levels. There is a criti...
Olivier Taboureau, Sonny Kim Nielsen, Karine Audou...
SC
2000
ACM
13 years 9 months ago
Data Access Performance in a Large and Dynamic Pharmaceutical Drug Candidate Database
An explosion in the amount of data generated through chemical and biological experimentation has been observed in recent years. This rapid proliferation of vast amounts of data ha...
Zina Ben-Miled, Yang Liu, David Powers, Omran A. B...
BMCBI
2006
138views more  BMCBI 2006»
13 years 4 months ago
Determination of strongly overlapping signaling activity from microarray data
Background: As numerous diseases involve errors in signal transduction, modern therapeutics often target proteins involved in cellular signaling. Interpretation of the activity of...
Ghislain Bidaut, Karsten Suhre, Jean-Michel Claver...
BMCBI
2010
191views more  BMCBI 2010»
13 years 4 months ago
BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions
Background: Genome-scale metabolic reconstructions under the Constraint Based Reconstruction and Analysis (COBRA) framework are valuable tools for analyzing the metabolic capabili...
Jan Schellenberger, Junyoung O. Park, Tom M. Conra...