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» Circadian signatures in rat liver: from gene expression to p...
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BMCBI
2010
179views more  BMCBI 2010»
12 years 11 months ago
Circadian signatures in rat liver: from gene expression to pathways
Background: Circadian rhythms are 24 hour oscillations in many behavioural, physiological, cellular and molecular processes that are controlled by an endogenous clock which is ent...
Meric A. Ovacik, Siddharth Sukumaran, Richard R. A...
BMCBI
2010
115views more  BMCBI 2010»
13 years 4 months ago
Importance of replication in analyzing time-series gene expression data: Corticosteroid dynamics and circadian patterns in rat l
Background: Microarray technology is a powerful and widely accepted experimental technique in molecular biology that allows studying genome wide transcriptional responses. However...
Tung T. Nguyen, Richard R. Almon, Debra C. DuBois,...
BMCBI
2006
117views more  BMCBI 2006»
13 years 4 months ago
Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comf
Background: Comfrey is consumed by humans as a vegetable and a tea, and has been used as an herbal medicine for more than 2000 years. Comfrey, however, is hepatotoxic in livestock...
Nan Mei, Lei Guo, Lu Zhang 0013, Leming M. Shi, Yo...
BMCBI
2007
101views more  BMCBI 2007»
13 years 4 months ago
Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats
Background: Pyrrolizidine alkaloids (PAs) are probably the most common plant constituents that poison livestock, wildlife, and humans worldwide. Riddelliine is isolated from plant...
Nan Mei, Lei Guo, Ruqing Liu, James C. Fuscoe, Tao...
BMCBI
2005
223views more  BMCBI 2005»
13 years 4 months ago
Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling
Background: The completion of the sequencing of human, mouse and rat genomes and knowledge of cross-species gene homologies enables studies of differential gene expression in anim...
Hong Fang, Weida Tong, Roger Perkins, Leming M. Sh...