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» Combinatorial Approaches to Finding Subtle Signals in DNA Se...
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BMCBI
2008
98views more  BMCBI 2008»
13 years 5 months ago
GBNet: Deciphering regulatory rules in the co-regulated genes using a Gibbs sampler enhanced Bayesian network approach
Background: Combinatorial regulation of transcription factors (TFs) is important in determining the complex gene expression patterns particularly in higher organisms. Deciphering ...
Li Shen, Jie Liu, Wei Wang
BMCBI
2002
120views more  BMCBI 2002»
13 years 5 months ago
tacg - a grep for DNA
Background: Pattern matching is the core of bioinformatics; it is used in database searching, restriction enzyme mapping, and finding open reading frames. It is done repeatedly ov...
Harry Mangalam
BMCBI
2010
113views more  BMCBI 2010»
13 years 5 months ago
Unifying generative and discriminative learning principles
Background: The recognition of functional binding sites in genomic DNA remains one of the fundamental challenges of genome research. During the last decades, a plethora of differe...
Jens Keilwagen, Jan Grau, Stefan Posch, Marc Stric...
BMCBI
2004
146views more  BMCBI 2004»
13 years 5 months ago
Defining transcriptional networks through integrative modeling of mRNA expression and transcription factor binding data
Background: Functional genomics studies are yielding information about regulatory processes in the cell at an unprecedented scale. In the yeast S. cerevisiae, DNA microarrays have...
Feng Gao, Barrett C. Foat, Harmen J. Bussemaker
GECCO
2007
Springer
258views Optimization» more  GECCO 2007»
13 years 9 months ago
TFBS identification by position- and consensus-led genetic algorithm with local filtering
Identification of Transcription Factor Binding Site (TFBS) motifs in multiple DNA upstream sequences is important in understanding the mechanism of gene regulation. This identific...
Tak-Ming Chan, Kwong-Sak Leung, Kin-Hong Lee