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» Comparative modeling without implicit sequence alignments
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BMCBI
2010
137views more  BMCBI 2010»
13 years 5 months ago
Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments
Background: While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor ...
Michael L. Sierk, Michael E. Smoot, Ellen J. Bass,...
JCB
2000
91views more  JCB 2000»
13 years 4 months ago
Scaling Laws and Similarity Detection in Sequence Alignment with Gaps
We study the problem of similarity detection by sequence alignment with gaps, using a recently established theoretical framework based on the morphology of alignment paths. Alignm...
Dirk Drasdo, Terence Hwa, Michael Lässig
BMCBI
2005
109views more  BMCBI 2005»
13 years 4 months ago
Genome comparison without alignment using shortest unique substrings
Background: Sequence comparison by alignment is a fundamental tool of molecular biology. In this paper we show how a number of sequence comparison tasks, including the detection o...
Bernhard Haubold, Nora Pierstorff, Friedrich M&oum...
LSSC
2007
Springer
13 years 11 months ago
An Ant-Based Model for Multiple Sequence Alignment
Abstract. Multiple sequence alignment is a key process in today’s biology, and finding a relevant alignment of several sequences is much more challenging than just optimizing so...
Frédéric Guinand, Yoann Pigné
BMCBI
2007
135views more  BMCBI 2007»
13 years 4 months ago
Automatic extraction of reliable regions from multiple sequence alignments
Background: High quality multiple alignments are crucial in the transfer of annotation from one genome to another. Multiple alignment methods strive to achieve ever increasing lev...
Timo Lassmann, Erik L. L. Sonnhammer