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» Comparative modeling without implicit sequence alignments
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WALCOM
2010
IEEE
230views Algorithms» more  WALCOM 2010»
14 years 1 months ago
Comparing RNA Structures with Biologically Relevant Operations Cannot Be Done without Strong Combinatorial Restrictions
Abstract. Arc-annotated sequences are useful for representing structural information of RNAs and have been extensively used for comparing RNA structures in both terms of sequence a...
Guillaume Blin, Sylvie Hamel, Stéphane Vial...
BMCBI
2007
147views more  BMCBI 2007»
13 years 6 months ago
MaxAlign: maximizing usable data in an alignment
Background: The presence of gaps in an alignment of nucleotide or protein sequences is often an inconvenience for bioinformatical studies. In phylogenetic and other analyses, for ...
Rodrigo Gouveia-Oliveira, Peter Wad Sackett, Ander...
BMCBI
2004
177views more  BMCBI 2004»
13 years 5 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
BMCBI
2004
208views more  BMCBI 2004»
13 years 5 months ago
Using 3D Hidden Markov Models that explicitly represent spatial coordinates to model and compare protein structures
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Vadim Alexandrov, Mark Gerstein
NAR
2006
128views more  NAR 2006»
13 years 6 months ago
Expresso: automatic incorporation of structural information in multiple sequence alignments using 3D-Coffee
Expresso is a multiple sequence alignment server that aligns sequences using structural information. The user only needs to provide sequences. The server runs BLAST to identify cl...
Fabrice Armougom, Sébastien Moretti, Olivie...